The Relationship between Total Ige and Neutrophils Count with Degrees of Asthma Control in Adult Atopic Patients

Eko E Surachmanto¹, Mochammad Hatta^2, , Andi Asadul Islam³ and Syarifuddin Wahid⁴

¹Department of Internal Medicine Faculty of Medicine, Sam Ratulangi University Manado, Indonesia

²Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

³Department of Neurosurgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

⁴Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Cite this paper

Eko E Surachmanto, Mochammad Hatta, Andi Asadul Islam and Syarifuddin Wahid. The Relationship between Total Ige and Neutrophils Count with Degrees of Asthma Control in Adult Atopic Patients. American Journal of Medical and Biological Research. 2018; 6(1):7-10. doi: 10.12691/AJMBR-6-1-2

Abstract

Introduction: Asthma is a chronic reversible inflammation which is caused by bronchial hypereactivity due to exposure to allergen and hyperproduction of certain specific IgE. Neutrophil in respiratory tract and high level of IgE in the blood serum is known to play in complex mechanism in asthma development. The role of total IgE serum and neutrophil serum in asthma development is still not well known. Aim: This study aim is to assess the correlation between level of total IgE and neutrophil serum with degree of asthma control. Methods: This is a cross sectional study with 35 adult subjects with atophy asthma (age 22-61), all of participant reside in Manado and its surrounding area. Degree of asthma control is categorized as intermittent, mild persistent, moderate persistent and severe persistent based on criteria by GINA. Patient with malignancy, sepsis, lung tuberculosis, diabetes mellitus, pregnant, and late stage chronic kidney disease are excluded from this study. Result: In this study there is no significant correlation between total IgE serum level and degree of asthma control (p>0.05.) also there is no significant correlation between each total IgE level and each degree of asthma control. There is significant positive correlation between neutrophil count and degree of asthma control (r = 0.309; p<0.05). The higher neutrophil count is higher in mild persistent asthma in comparison with intermittent asthma is found to be significant (p<0.05). Conclusion: The neutrophil count in serum is related to degree of asthma control. Especially neutrophil count in mild persistent is higher than intermittent asthma. There is no correlation between total IgE level with degree of asthma control in adult subject with atopic asthma.

Keywords

atopic asthma, total Ig E, neutrophil count, degree of asthma control

Copyright

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