American Journal of Medical and Biological Research

The extracellular matrix protein tenascin-C (TNC) is up-regulated in many cancers including breast cancer. TNC is associated with tumour progression and poor prognosis. The aim of this study was to investigate the effects of TNC knockdown on global gene expression in TNC expressing invasive breast cancer cell lines. Breast cancer cell lines (MDA-MB-231 and MDA-MB-436) were transfected with small interfering RNA (siRNAs) targeting total TNC. cDNA microarray was used to analyse the effects of TNC knockdown on global gene expression at the mRNA level. Microarray analysis following total TNC knockdown revealed significant changes in gene expression: CREBL2, YWHAE and RRAS2 showed down regulation and QKI was specifically up-regulated. In conclusion, the silencing of TNC expression caused significant alteration on global genes expression associated with tumour progression.

American Journal of Medical and Biological Research. 2015, 3(2), 62-67. DOI: 10.12691/ajmbr-3-2-3
Pub. Date: April 29, 2015

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Hypertriglyceridemia Induced Acute Pancreatitis in Pregnancy

by Adil Elghanmi, Ilham Bahra, Fatima Ezzahara Nour and Hicham Seffar

Case Report

Hypertriglyceridemia induced acute pancreatitis in pregnancy is a rare and life threatening situation.This pathology is associated with high maternal and fetal mortality and morbidity. Case report: A 24 years old Moroccan women Para 1 Gravida 1 was presented to our Emergency Department of Gynecology and Obstetrics of Moulayabdeallah Hospital, Essaouira, Morocco, at 38 weeks of gestation for acute onset of abdominal pain and uterine contractions. Physical exam revealed signs of severe sepsis. Immediate measures of resuscitation were performed. Emergent cesarean delivery and laparotomy revealed chylous ascites in the abdomen. Blood tests showed a high rate of triglyceride. Through this case report, we want to raise awareness of this medical situation that require immediate recognition because any delay can cause catastrophic consequences for both, the mother and the fetus.

American Journal of Medical and Biological Research. 2015, 3(2), 53-54. DOI: 10.12691/ajmbr-3-2-1
Pub. Date: April 17, 2015

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