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American Journal of Medical and Biological Research. 2015, 3(3), 68-73
DOI: 10.12691/AJMBR-3-3-1
Research Article

Oxidative Stress Markers in Pregnant Women with Preeclampsia

Leidiane de Lucca1, Francisco Maximiliano Pancich Gallarreta2 and Thissiane de Lima Gonçalves1,

1Postgraduate Program in Pharmaceutical Sciences, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), Santa Maria (RS), Brazil

2Departamet of Obstetrics and Gynecology, Federal University of Santa Maria (UFSM), Santa Maria (RS), Brazil

Pub. Date: May 31, 2015
(This article belongs to the Special Issue Advances in gynecology and obstetrics)
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Leidiane de Lucca, Francisco Maximiliano Pancich Gallarreta and Thissiane de Lima Gonçalves. Oxidative Stress Markers in Pregnant Women with Preeclampsia. American Journal of Medical and Biological Research. 2015; 3(3):68-73. doi: 10.12691/AJMBR-3-3-1

Abstract

Preeclampsia is a very important multisystem disorder to be specific to pregnancy, it is a disease mainly characterized by hypertension and proteinuria, but with unknown etiology that exposes the mother and the newborn to serious risks. One of the main factors involved in the pathophysiology of preeclampsia is oxidative stress and the rate of oxidative stress is measured by the ratio between the reactive oxygen species produced in the body called free radicals, and antioxidants produced by the body or absorbed through the diet. The excess of these free radicals have harmful effects, such as peroxidation of membrane lipids and aggression to tissue and membranes proteins as well as to membranes, enzymes, carbohydrates and DNA. Hypertensive disorders in pregnancy are a major cause of morbidity and maternal and fetal mortality. Preeclampsia is classified as a type of hypertensive complication that affects many pregnant women worldwide. The pregnancy and preeclampsia are conditions that increase susceptibility to oxidative stress, which in turn contributes to numerous complications, further aggravating the condition.

Keywords

Oxidative Stress, Pregnancy, Preeclampsia, Biomarkers

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Machado, S., Neves, M., Freitas, L., Campos, M., Diagnosis, pathophysiology and management of pre-eclampsia: a review, Port J Nephrol Hypert, 27 (3). 153-161. 2013.
 
[2]  Ministério da saúde. Atenção ao pré-natal de baixo risco. Cadernos de Atenção Básica, 32. 88-92. 2012.
 
[3]  Farag, K., Hassan, I., Ledger, W.L., Prediction of preeclampsia; can it be achieved? Obstet Gynecol Surv, 59. 464-38. 2004.
 
[4]  Sibai, B.M., Dekker, G.A., Kuplerminc, M. Preeclampsia, The Lancet, 365 (26). 785-799. 2005.
 
[5]  Hladunewich, M., Karumanchi, S.A., Lafayette, R., Pathophysiology of the clinical manifestations o pre-eclampsia, Clin J Am Soc Nephrol, 2 (3). 543-549. 2007.
 
[6]  Mutter, W.P., Karumanchi, A.S., Molecular mechanisms of pre-eclampsia, Microvasc Res, 75 (1). 1-8. 2008.
 
[7]  Magnussen, E.B., Vatten, L.J., Smith, G.D., Romundstad, P.R, Hypertensive Disorders in pregnancy and subsenquently measured cardiovascular risk factors, Obstet Gynecol, 114 (5). 961-970. 2009.
 
[8]  Greene, M.F., Magnesium Sulfate for Preeclampsia. N Engl J Med, 348. 275-276. 2003.
 
[9]  Rudge, M.V.C., Vasconcellos, M.J.A., Diabetes e hipertensão na gravidez: Manual de orientação, FEBRASGO, Federação Brasileira das Associações de Ginecologia e Obstetrícia, São Paulo, 3. 2004.
 
[10]  Taniyama Y., Griendling K.K., Reactive oxygen species in the vasculature: Molecular and cellular mechanisms, Hypertension, 42. 1075-108. 2003.
 
[11]  Lutoslawska, G., Tkaczyk, J., Panczenko-Kresowska, B., Hubner-Wozniak, E., Skierska, E., Gajewski, A., Plasma TBARS, blood GSH concentration, and erythrocyte antioxidant enzyme activities in regularly menstruating women with ovulatory and anovulatory menstrual cycles, Clinica Chimica Acta, 331. 159-163. 2003.
 
[12]  Barreiros, A.L.B.S., David, J.M., Estresse oxidativo: relação entre geração de espécies reativas e defesa do organismo, Quim. Nova, 29. 113-123. 2006.
 
[13]  Ferreira, A.L.A, Matsubara, L.S., Radicais livres: conceitos, doenças relacionadas, sistema de defesa e estresse oxidativo, Rev Assoc Méd Bras, 43. 61-68. 1997.
 
[14]  Trindade, C.E.P., Rugolo, L.M.S.S., Free radicals and neonatal diseases, Neoreviews, 8. 522-532. 2007.
 
[15]  Agarwal, A., Gupta, S., Sharma, R.K., Role of oxidative stress in female reproduction, Rep Biol Endocr, 3. 28. 2005.
 
[16]  Raijimakers, M.T.M., Peters, W.H.M., Steegers, E.A.P., Poston, L., Amino thiols, detoxification and oxidative stress in pre-eclampsia and other disorders of pregnancy, Curr Pharmaceut Design, 11 (6). 711-734. 2005.
 
[17]  Myatt, L., Cui, X., Oxidative stress in placenta. Histochem Cell Biol, 122. 369-382. 2004.
 
[18]  Fainaru, O., Almog, B., Pinchuk, I., Kupferminc, M.J., Lichtenberg, D., Many A., Active labour is associated with increased oxidisibility of serum lipids ex vivo, BJOG, 109. 938-941. 2002.
 
[19]  Mocatta, T.J., Winterbourn, C.C., Inder, T.E., Darlow, B.A., The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma, Free Rad Res, 38. 185-191. 2004.
 
[20]  Wall, P.D., Pressman, E.K., Woods J.R., Preterm premature rupture of the membranes and antioxidants: the free radical connection, J Perinat Med, 30. 447-457. 2002.
 
[21]  Pressman, E.K., Cavanaugh, J.L., Mingione, M., Norkus, E.P., Woods, J.R., Effects of maternal antioxidant supplementation on maternal and fetal antioxidant levels: a randomised, double blind study, Am J Obstet Gynecol, 189.1720-1725. 2003.
 
[22]  Abuja, P. M., Albertini, R., Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistence of lipoproteins, Clin Chim Acta, 306. 1-17. 2001.
 
[23]  Halliwell, B., Gutteridge, J.M.C., Free radical in biology and medicine, Oxford Universit Press, 2ed. New York. 1989.
 
[24]  Kyle, M.E., Farber, J.L. Biochemical mechanisms of toxic cell injury. In: Haschek, W.M.; Rousseaux, C.G.; editors. Handbook of Toxicologic Pathology. New York: Academic Press Inc, 71-89. 1991.
 
[25]  Serdar, Z., Gur, E., Colakoethullary, M., Develioethlu, O., Sarandol, E., Lipid and protein oxidation and antioxidant function in women with mild and severe preeclampsia, Arch Gynecol Obstet, 268. 19-25. 2003.
 
[26]  Mehendale, S., Kilari, A., Dangat, K., Taralekar, V., Mahadik, S., Joshi, S., Fatty acids, antioxidants, and oxidative stress in pre-eclampsia. Int J Gynecol Obstet,.
 
[27]  Casanueva, E., Viteri, F.E., Iron and oxidative stress in pregnancy. J Nutr, 133. 1700S-8S. 2003.
 
[28]  Toescu, V., Nuttall, S.L., Martin, U., Nightingale, P., Kendall, M.J., Brydon, P. et al., Changes in plasma lipids and markers of oxidative stress in normal pregnancy and pregnancies complicated by diabetes, Clin Sci, 106. 93-98. 2004.
 
[29]  Jauniaux, E., Watson, A. L., Hempstock, J., Bao, Y.P., Skepper, J.N., Burton, G.J., Onset of maternal arterial blood flow and placental oxidative stress, Am J Pathol, 157 (6). 2111-2122. 2000.
 
[30]  Raijmakers, M.T.M., Steegers, E.A.P., Peters, W.H.M., Glutatione S-Transferases and thiol concentrations in embryonic and early fetal tissues, Hum Reprod, 16 (11). 2445-2450. 2001.
 
[31]  Chaooell, L.C., Seed, P.T., Briley, A., et al., A longitudinal study of biochemical variables in women at risk of preeclampsia, Am J Obstet Gynecol, 187 (1). 127-136. 2002.
 
[32]  Cikot, R.J.L.M., Steegers Theunissen, R.P.M., Thomas, C.M.G., de Boo, T.M., Merkus, H.M.W.M, Steegers, E.A.P., Longitudinal vitamin and hemocysteine levels in normal pregnancy, Br J Nutr, 85 (1). 49-58. 2001.
 
[33]  Wilson, M.L., Goodwin, T.M., Pan, V.L. et al., Molecular epidemiology of preeclampsia, Obstet Gynecol Survey, 58. 39-65. 2003.
 
[34]  Rodrigo, R., Parra, M., Bosco, C., Fernández, V., Barja, P., Guajardo, J., Messina, R., Pathophysiological basis for the prophylaxis of preeclampsia through early supplementation whith antioxidant vitamins, Pharmacol Therapeut, 107. 177-197. 2005.
 
[35]  Uotila, J.T., Tuimala, R.J.,Aarnio, T., Pyykko, K., Ahotupa, M., Lipid peroxidation products, selenium-dependent glutathione peroxidase and vitamin E in normal pregnancy, Eur J Obstet Gynaecol Reprod Biol, 42 (2). 95-100. 1991.
 
[36]  Burton, G.J., Hung, T.H., Hypoxiareoxygenation; a potencial source of placental oxidatives stress in normal pregnancy and preeclampsia, Fetal Maternal Med Rev, 14 (2). 97-117. 2003.
 
[37]  Xiong, X., Demianczuk, N.N., Saunders, L.D., Wang, F.L., Fraser, W.D., Impact of preeclampsia and gestational hypertension on birth weight by gestational age, Am J Epidemiol, 155. 203-209. 2002.
 
[38]  Tsukahara, H., Jiang, M.Z., Ohta, N., Sato, S., Tamura, S., Hiraoka, M., et al., Oxidative stress in neonates: evaluation using specific biomarkers, Life Sci, 75. 933-938. 2004.
 
[39]  Weinberger, B., Nisar, S., Anwar, M., Ostfeld, B., Hegyi, T., Lipid peroxidation in cord blood and neonatal outcome, Pediatr Int, 48. 479-483. 2006.
 
[40]  Tanir, H.M., Sener, T., Inal, M., Akyuz, F., Uzuner, K., Siyri, E., Effect of quercetine and glutathione on the level of superoxide dismutase, catalase, malonyldialdehyde, blood pressure and neonatal outcome in a rat model of pre-eclampsia induced by NG-nitro-L-arginine-methyl ester, Eur J Obstet Gynecol Reprod Biol, 118. 190-195. 2005.
 
[41]  Dotan, Y., Lichtenberg, D., Pinchuk, I., Lipid peroxidation cannot be used as a universal criterion of oxidative stress. Prog Lipid Res, 43. 200-227. 2004.
 
[42]  Alexandrova, M.L., Bochev, P.G., Oxidative stress during the chronic phase after stroke, Free Radical Biology and Medicine, 39. 297-316. 2005.
 
[43]  Cherubini, A., Ruggiero, C., Polidori, M.C., Mecocci, P., Potential markers of oxidative stress in stroke, Free Radical Biology & Medicine, 39. 841-852. 2005.
 
[44]  Kashyap, M.K., Yadav, V., Sherawat, B.S., Jain, S., Kumari, S., Khullar, M., Sharma, P.C., Nath, R., Different antioxidants status, total antioxidant power and free radicals in essential hypertension, Molecular and Cellular Biochemistry, 277. 89-99. 2005.
 
[45]  Halliwell, B., Gutteridge, J.M.C., Antioxidant defence mechanisms: From the beginning to the end (of the beginning), Free Radic Res, 31. 261-272. 1999.
 
[46]  Jacob, R. F., Mason, R. P., Lipid peroxidation induces cholesterol domais formation in model membranes, J Biol Chen, 280. 39380-39387. 2005.
 
[47]  Ilhan, N., Ilhan, N., Simsek, M., the changes of trace elements malonaldehyde levels and superoxide dimuthase activities in pregnancy with or without pre-eclampsia, Clin Biochem, 35 (5). 393-397. 2002.
 
[48]  Basbug M., Demir I., Sernil S. et al., Maternal erythrocyte malondialdehyde level inpreeclampsia prediction: a longitudinal study, J Perinat Med, 31 (6). 469-474. 2003.
 
[49]  Shanklin, D.R., Sibai, B.M., Ultrastructural aspects of preeclampsia: I. Placental bed and uterine boundary vessels, Am J Obstet Gynecol, 161. 735-740. 1989.
 
[50]  Kendall, M.J., Nuttall S.L., Antioxidant therapy for the treatment of coronary artery disease. Expert opinion in investigative, Drugs, 8. 1763-1784. 1999.
 
[51]  HU, M. L., Measurement of protein thiol groups and glutathione in plasma, Methods Enzymol, 233. 380-385. 1994.
 
[52]  Coelho, M.C., Martins, G.M., Viana, E., Mesquita, M.R.S., Camano, L., Sass, N., Proteinúria nas síndromes hipertensivas da gestação: prognóstico materno e perinatal, Rev Assoc Med Bras, 50 (2). 207-213. 2004.
 
[53]  Halliwell, B., The antioxidant paradox, The lancet, 355. 1179-1180. 2000.
 
[54]  Halliwell, B, Gutteridge, J.M.C., Role of free radicals and catalytic metal ions in human disease: an overview, Methods in Enzimology, 186. 1-5. 1990.
 
[55]  Krinsky, N.I., The antioxidant and biological properties of the carotenoids, Ann N Y Acad Sci, 854. 443-447. 1998.
 
[56]  Tomaro, M.L., Batlle, A.M., Bilirubin: its role in cytoprotection against oxidative stress, Int J Biochem Cell Biol, 34 (3). 216-220. 2002.
 
[57]  Mikhail, M. S., Anyaegbunam, A., Garfinkel, D., Palan, R. P., Basu, J., Romney, S. L., Preeclampsia and antioxidant nutrients: decreased plasma levels of reduced ascorbic acid, a-tocopherol, and h-carotene in women with preeclampsia, Am J Obstet Gynecol, 171. 150-157. 1994.
 
[58]  Hubel, C. A., Kagan, V. E., Kisin, E. R., Mclaughlin, M. K., Roberts, J. M., Increased ascorbate radical formation and ascorbate depletion in plasma from women with preeclampsia: implications for oxidative stress, Free Radic Biol Med, 23. 597-609. 1997.
 
[59]  Hubel, C. A. Oxidative stress in the pathogenesis of preeclampsia, Proc Soc Exp Biol Med, 222. 222-235. 1999.
 
[60]  Mutlu-Turkoglu, U., Ademoglu, E., Ibrahimoglu, L., Aykac-Toker, G., Uysal, M., Imbalance between lipid peroxidation and antioxidant status in preeclampsia, Gynecol Obstet Invest, 46. 37-40. 1998.
 
[61]  Roberts, J. M., Lain, K. Y., Recent insights into the pathogenesis of pre-eclampsia, Placenta, 23. 359-372. 2002.
 
[62]  Chappell, L. C., Seed, P. T., Briley, A. L., Kelly, F. J., Lee, R., Hunt, B. J., Parmar, K., Bewley, S. J., Shennan, A. H., Steer, P. J., Poston, L., Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial, Lancet, 354. 810-816. 1999.
 
[63]  Chappell, L. C., Seed, P. T., Kelly, F. J., Briley, A., Hunt, B. J., Charnock-Jones, D. S., Mallet, A., Poston, L., Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function, Am J Obstet Gynecol, 187. 777-784. 2002.
 
[64]  Poston, L., Briley, A.L., Seed, P.T., Kelly, F.J., Shennan, A.H., Vitamins in preeclampsia (VIP) Trial Consortium, vitamin C and vitamin E in pregnant women at risk for preeclampsia (VIP trial): randomized pacebo-controlled trial, Lancet, 367. 1145-1154. 2006.
 
[65]  Rumbold, A.R., Crowther, C.A., Haslam, R.R., Dekker, G.A., Robinson, J.S., ACTS Study Group. Vitamins C and E and the risks of preeclampsia and perinatal complications, N Engl J Med, 354. 1796-1806. 2006
 
[66]  Sies, H., Stahl, W., Sundquist, A. R., Antioxidant functions of vitamins: vitamins E and C, beta carotene, and other carotenoids, Ann N Y Acad Sci, 669. 7-20. 1992.
 
[67]  Nordberg, J., Arner, E.S., Reactive oxygen species, antioxidants, and the mammalian thioredoxin system, Free Rad Biol Med, 31 (11). 1287-1312. 2001.
 
[68]  Gitto E., Reiter, R.J., Karbownik, M., Tan, D.X., Gitto, P., Barberi, S., Barberi, I., Causes of Oxidative Stress in the Pre-and Perinatal Period, Biol Neonate, 81. 146-157. 2002.
 
[69]  Touyz, R., Paravicini, T., NADPH oxidases, reactive oygen species and hypertension, Diabetes Cate, 31. 170-180. 2008.
 
[70]  Ross, D., Moldeus, P., Antioxidant defenses systems and oxidative stress. In Vigo Pelfrey C (ed): Membrane lipid oxidation. Ith ed. Boca Raton, CRC Press. 151-170. 1991.
 
[71]  Achyara, J. et al., Red cell lipid peroxidation and antioxidant enzymes in iron deficiency, Eur J Haematol, 47. 287-291. 1991.
 
[72]  Mates, J.M., Perez-Gomez, C., Nunez, D.C., Antioxidant enzymes and human diseases, Clin Biochem, 32 (8). 595-603. 1999.
 
[73]  Wieacker, P., Mueller, C.R., Mayerova, A., Grzeschik, K.H., Ropers, H.H., Assignment of the gene coding for human catalase to the short arm of chromosome 11, Ann Genet, 23. 73-77. 1980.
 
[74]  Sassa, S., ALA-D, Porphyria. Semin Liver Dis, 18. 95-101. 1998.
 
[75]  Gabriel, D., Pivetta, L., Folmer, V., Soares, J.C., Augusti, G.R., Nogueira, C.W., Zeni, G., Rocha, J.B., Human erythrocyte delta-aminolevulinate dehydratase inhibition by monosaccharides is not mediated by oxidation of enzyme sulfhydryl groups, Cell Biology International, 29. 669-674. 2005.
 
[76]  Bechara, E.J.H., Medeiros, M.H.G., Monteiro, H.P., Hermes-Lima, M., Pereira, B., Demasi, M., Costa, C.A., Abdalla, D.S.P., Onuki, P., Wendel, C.M.A., Di Mascio, P., A Free Radical Hypothesis of Lead Poisoning and Inborn Porphyrias Associated with 5-Aminolevulinic Acid Overload, Química Nova, 16. 385-392. 1993.
 
[77]  Perreira, B., Curi, R., Kokubun, E., Bechara, E.J., 5-Aminolevulinic acid-induced alterations of oxidative metabolism in sedentary and exercise-trained rats, J Appl Physiol, 72. 226-230. 1992.
 
[78]  Farina, M., Barbosa, N.B., Nogueira, C.W., Folmer, V., Zeni, G., Andrade, L.H., Braga, A.L., Rocha, J.B., Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves., Braz J Med Biol Res, 35 (6). 623-631. 2002.
 
[79]  Nogueira, C.W., Soares, F.A., Nascimento, P.C., Muller, D., Rocha, J.B., 2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury-and cadmium-induced inhibition of delta-aminolevulinate dehydratase, Toxicology, 184 (2-3). 85-95. 2003.
 
[80]  Nogueira, C. W., Borges, V. C., Zeni, G., Rocha, J. B., Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro, Toxicology, 191 (2-3). 169-178. 2003.
 
[81]  Santos, F. W., Oro, T., Zeni, G., Rocha, J.B., do Nascimento, P.C., Nogueira, C.W., Cadmium induced testicular damage and its response to administration of succimer and diphenyl diselenide in mice, Toxicol Lett, 152 (3). 255-263. 2004.
 
[82]  Bechara, E.J. Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid, Braz J Med Biol, 29. 841-851. 1996.
 
[83]  Costa, C.A., Trivelato, G.C., Pinto, A.M., Bechara, E.J., Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers, Clin Chem, 43. 1196-1202. 1997.
 
[84]  Chamy, V.M., Lepe, J., Catalán, A., Retamal, D., Escobar, J.A., Madrid, E.M., Oxidative stress is closely related to clinical severity of pre-eclampsia, Biol Res, 39. 229-236. 2006.